Metabolite acetyl-L-carnitine participates in <i>Bif. Animalis</i> F1-7 to ameliorate atherosclerotic inflammation by downregulating theTLR4/NFκB pathway
نویسندگان
چکیده
This study aimed to explore the effect of Bif. Animalis F1-7 on improvement atherosclerotic inflammation. Arteriosclerosis model ApoE-/- mice were orally administered with for 12 weeks. The probiotic intervention reduced plaque areas in aorta and accumulation macrophages, downregulated expression toll-like receptor 4 (TLR4)/nuclear factor‑κB (NFκB) pathway reduce levels inflammatory factors. widely-targeted metabolomics analysis showed that acetyl-L-carnitine (ALC) intestine was significantly increased after intervention.Correlation proved ALC associated response. By using ox-LDL induced macrophage foam cells, we further verified could lipid response cells by downregulating TLR4/NFκB pathway. Finally, our results revealed upregulated metabolite downregulate responses, leading reduction atherosclerosis.
منابع مشابه
Acetyl-L-Carnitine Monograph
Introduction Acetyl-L-carnitine (ALC) is an ester of the trimethylated amino acid, L-carnitine, and is synthesized in the human brain, liver, and kidney by the enzyme ALC-transferase. Acetyl-L-carnitine facilitates the uptake of acetyl CoA into the mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis. ALC, simila...
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ژورنال
عنوان ژورنال: Food Science and Human Wellness
سال: 2023
ISSN: ['2213-4530']
DOI: https://doi.org/10.26599/fshw.2022.9250069